PDB ID or protein name

1pfx » Coagulation factor IX

1pfx » Coagulation factor IX
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1pfx » Coagulation factor IX
Depth 1.9 ± 6.0 Å
Tilt Angle 84 ± 10°
ΔGtransfer -3.9 kcal/mol
Links to 1pfx PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology extracellular
Resolution 3.0 Å
Other PDB entries representing this structure 1x7a
Number of subunits 2
Experimental Verification for 1pfx » Coagulation factor IX
Orientation of the complex should be more perpendicular to the membrane based on a fluorescence study by Mutucumarana et al. (1992).
1 reference
Mutucumarana, V.P., Duffy, E.J., Lollar, P., and Johnson, A.E. 1992. The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa. A fluorescence study. J. Biol. Chem. 267:17012 PubMed
Comments on 1pfx » Coagulation factor IX
Heterodimer of a light chain and a heavy chain; disulfide-linked. Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Activated by factor XIa, which excises the activation peptide.