PDB ID or protein name

1po5 » Cytochrome P450 2B4, open state 2

1po5 » Cytochrome P450 2B4, open state 2
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1po5 » Cytochrome P450 2B4, open state 2
Hydrophobic Thickness 3.5 ± 1.4 Å
Tilt Angle 79 ± 9°
ΔGtransfer -7.2 kcal/mol
Links to 1po5 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.6 Å
Other PDB entries representing this structure none
Number of TM subunits 1
Experimental Verification for 1po5 » Cytochrome P450 2B4, open state 2
This cytochrome presumably forms TMH 1-21, consistent with calculated orientation.
Comments on 1po5 » Cytochrome P450 2B4, open state 2
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.