- Protein Classification
- Protein Links
 | lumenal side |
| cytoplasmic side |
| 1pq2 » Cytochrome P450 2C8 | |
|---|---|
| Hydrophobic Thickness | 3.8 ± 1.8 Å |
| Tilt Angle | 65 ± 9° |
| ΔGtransfer | -8.6 kcal/mol |
| Links to 1pq2 | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | cytoplasmic |
| Resolution | 2.7 Å |
| Other PDB entries of this protein | 2nnh, 2nni, 2nnj, 2vn0 |
| Number of TM subunits | 1 |
| Experimental Verification for 1pq2 » Cytochrome P450 2C8 |
|---|
| Crystallization with detergent (CYMAL-6). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation. |
| Comments on 1pq2 » Cytochrome P450 2C8 |
|---|
| Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol). |
