PDB ID or protein name

1pq2 » Cytochrome P450 2C8

1pq2 » Cytochrome P450 2C8
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1pq2 » Cytochrome P450 2C8
Hydrophobic Thickness 3.8 ± 1.8 Å
Tilt Angle 65 ± 9°
ΔGtransfer -8.6 kcal/mol
Links to 1pq2 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.7 Å
Other PDB entries representing this structure 2nnh, 2nni, 2nnj, 2vn0
Number of TM subunits 1
Experimental Verification for 1pq2 » Cytochrome P450 2C8
Crystallization with detergent (CYMAL-6). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation.
Comments on 1pq2 » Cytochrome P450 2C8
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).