PDB ID or protein name

1ptr » C1 domain of protein kinase C delta

1ptr » C1 domain of protein kinase C delta
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1ptr » C1 domain of protein kinase C delta
Depth 6.6 ± 1.5 Å
Tilt Angle 19 ± 8°
ΔGtransfer -5.9 kcal/mol
Links to 1ptr PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.20 Å
Other PDB entries of this protein 1ptq
Number of subunits 1
Experimental Verification for 1ptr » C1 domain of protein kinase C delta
The protein penetrates deeper into the membrane core when bound to the acetyl phorbol ligand, according to the calculations (this model). M239, S240, P241, F243, L250, W252, G253, L254 and V255 are buried in the membrane core in the ligand-bound state are, consistent with the important role of L250, W252 and L254 in protein-lipid interactions (Wang et al. 2001).
1 reference
Wang QJ, Fang TW, Nacro K, Marquez VE, Wang S, Blumberg PM. 2001. Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions. J Biol Chem. 276:19580-7. PubMed
Comments on 1ptr » C1 domain of protein kinase C delta
Protein kinase C delta is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC also serves as the receptor for phorbol esters, a class of tumor promoters (13-acetylphorbol in the PDB structure).