1ptr » C1 domain of protein kinase C delta
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Topology in Eukaryotic plasma membrane
Download Coordinates
Topology in Eukaryotic plasma membrane
 | extracellular side |
| cytoplasmic side |
- Type: 2. Monotopic/peripheral (4 classes)
- Class: 2.2. All beta monotopic/peripheral (42 superfamilies)
- Superfamily: 2.2.27. C1 domain (1 family)
- Family: 2.2.27.01. Protein kinase C1 domain (8 proteins)
- Species: Mus musculus (33 proteins)
- Localization: Eukaryotic plasma membrane (198 proteins)
| 1ptr » C1 domain of protein kinase C delta | |
|---|---|
| Depth | 6.8 ± 1.7 Å |
| Tilt Angle | 10 ± 19° |
| ΔGtransfer | -5.7 kcal/mol |
| Links to 1ptr | PDB Sum, SCOP, MSD, OCA, MMDB, Dali |
| Topology | cytoplasmic |
| Resolution | 2.20 Å |
| Related PDB Sum entries | 1ptq |
| Number of subunits | 1 |
| Experimental Verification for 1ptr » C1 domain of protein kinase C delta |
|---|
| Residues that are buried in the membrane hydrophobic core are M239, S240, P241, F243, L250, W252, G253, L254 and V255. This is consistent with the important role of L250, W252 and L254 in protein-lipid interactions (Wang et al. 2001). |
| 1 reference |
|---|
| Wang QJ, Fang TW, Nacro K, Marquez VE, Wang S, Blumberg PM. 2001. Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions. J Biol Chem. 276:19580-7. PubMed |
| Comments on 1ptr » C1 domain of protein kinase C delta |
|---|
| Protein kinase C delta is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC also serves as the receptor for phorbol esters, a class of tumor promoters (13-acetylphorbol in the PDB structure). |
