- Protein Classification
- Protein Links
| 1pub » Ganglioside GM2 activator, different conformation | |
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| Depth | 4.9 ± 0.7 Å |
| Tilt Angle | 50 ± 8° |
| ΔGtransfer | -7.3 kcal/mol |
| Links to 1pub | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | out |
| Resolution | 2.5 Å |
| Other PDB entries of this protein | 1g13, 1pu5, 1tjj, 2af9, 2ag2, 2ag4, 2ag9 |
| Number of subunits | 1 |
| Experimental Verification for 1pub » Ganglioside GM2 activator, different conformation |
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| GM2 activator interacts with lipid bilayers (Giehl et al. 1999). Calculated orientation is in agreement with membrane binding mode proposed by Wright et al. (2003). |
| 2 references |
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| Giehl A, Lemm T, Bartelsen O, Sandhoff K, Blume A. 1999. Interaction of the GM2-activator protein with phospholipid-ganglioside bilayer membranes and with monolayers at the air-water interface. Eur J Biochem. 261:650-8. PubMed |
| Wright CS, Zhao Q, Rastinejad F. 2003. Structural analysis of lipid complexes of GM2-activator protein. J Mol Biol. 331:951-64. PubMed |
| Comments on 1pub » Ganglioside GM2 activator, different conformation |
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| Extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. |
