PDB ID or protein name

1pxq » Subtilosin A

1pxq » Subtilosin A
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Topology in Secreted
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1pxq » Subtilosin A
Depth 7.6 ± 0.8 Å
Tilt Angle 86 ± 3°
ΔGtransfer -9.3 kcal/mol
Links to 1pxq PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1pxq » Subtilosin A
Results are consistent with the partially buried location of subtilosin A in lipid bilayers parallel to the membrane surface, and Trp34 facing towards the center of the lipid bilayer (Thennarasu et al. 2005).
1 reference
Thennarasu S, Lee DK, Poon A, Kawulka KE, Vederas JC, Ramamoorthy A. 2005. Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chem. Phys. Lipids. 137:38-51. PubMed
Comments on 1pxq » Subtilosin A
This peptide undergoes unique processing steps that include proteolytic cleavage after Glu-8, and covalent linkage of the alpha-amino of Asn-9 with the carboxyl of Gly-43 to form a cyclopeptide. Thioether cross-links are formed between cysteines and the alpha-carbons of other amino acids, Cys-12 to Phe-39, Cys-15 to Thr-36, and Cys-21 to Phe-30. In forming these cross-links, Thr-36 and Phe-39 are converted to D-amino-acids.