PDB ID or protein name

1qfg » Ferric hydroxamate uptake receptor FhuA

1qfg » Ferric hydroxamate uptake receptor FhuA
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Topology in Bacterial Gram-negative outer membrane
Topologyout side
in side
1qfg » Ferric hydroxamate uptake receptor FhuA
Hydrophobic Thickness 24.7 ± 1.0 Å
Tilt Angle 5 ± 1°
ΔGtransfer -81.3 kcal/mol
Links to 1qfg PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus in)
Resolution 2.50 Å
Other PDB entries representing this structure 1by3, 1by5, 1fcp, 1fi1, 1qff, 1qjq, 1qkc, 2fcp
Number of TM Secondary Structures 22
1 transmembrane subunit
A - Tilt: 1° - Segments: 1(161-170), 2(173-182), 3(191-199), 4(212-221), 5(228-236), 6(280-288), 7(294-303), 8(355-365), 9(372-380), 10(443-453), 11(456-465), 12(487-497), 13(501-509), 14(531-540), 15(545-552), 16(580-589), 17(593-601), 18(624-633), 19(641-649), 20(668-676), 21(685-692), 22(716-724)
Experimental Verification for 1qfg » Ferric hydroxamate uptake receptor FhuA
Average tilt of TM beta-strands (38°) is slightly smaller than estimated by ATR FTIR spectroscopy (44°)(Ramakrishnan et al. 2005).
1 reference
Ramakrishnan M, Qu J, Pocanschi CL, Kleinschmidt JH, and Marsh D (2005) Orientation of beta-barrel proteins OmpA and FhuA in lipid membranes. Chain length dependence from infrared dichroism. Biochemistry 44: 3515-3523. PubMed
Comments on 1qfg » Ferric hydroxamate uptake receptor FhuA
This receptor binds the ferrichrome-iron ligand. It interacts with the tonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin.