PDB ID or protein name

1qow » Mersacidin, crystal structure

1qow » Mersacidin, crystal structure
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Topology in Secreted
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1qow » Mersacidin, crystal structure
Hydrophobic Thickness or Depth 3.2 ± 2.7 Å
Tilt Angle 72 ± 31°
ΔGtransfer -5.5 kcal/mol
Links to 1qow PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.0 Å
Other PDB entries representing this structure none
Number of subunits 3
Experimental Verification for 1qow » Mersacidin, crystal structure
Peptide forms hexamer in the crystal (Schneider et al. 2000). However, it can be inserted in the lipid bilayer only as trimer or monomer .
1 reference
Schneider TR, Karcher J, Pohl E, Lubini P, Sheldrick GM. 2000. Ab initio structure determination of the lantibiotic mersacidin. Acta Crystallogr D56: 705-713. PubMed
Comments on 1qow » Mersacidin, crystal structure
Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The carboxy-terminal beta-methyllanthionine undergoes decarboxylation. This is followed by membrane translocation and cleavage of the modified precursor.