PDB ID or protein name

1r9o » Cytochrome P450 2C9, different conformation

1r9o » Cytochrome P450 2C9, different conformation
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1r9o » Cytochrome P450 2C9, different conformation
Hydrophobic Thickness 4.0 ± 1.1 Å
Tilt Angle 59 ± 8°
ΔGtransfer -10.1 kcal/mol
Links to 1r9o PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.0 Å
Other PDB entries of this protein none
Number of TM subunits 1
Comments on 1r9o » Cytochrome P450 2C9, different conformation
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.