PDB ID or protein name

1rer » E1 envelope glycoprotein

1rer » E1 envelope glycoprotein
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Topology in Viral membrane
Topologyout side
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1rer » E1 envelope glycoprotein
Hydrophobic Thickness 2.6 ± 2.0 Å
Tilt Angle 38 ± 5°
ΔGtransfer -6.5 kcal/mol
Links to 1rer PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 3.2 Å
Other PDB entries representing this structure 1dyl, 1i9w, 1vcq, 2ala, 2v33
Number of TM subunits 3
Experimental Verification for 1rer » E1 envelope glycoprotein
Structures of mononers in the trimer are slightly different. The symmetry axis of the trimer is strongly tilted. It is also tilted according to EM data. A really symmetric structure is a pentamer of the trimers (Gibbons et al. 2004).
1 reference
Gibbons DL, Vaney MC, Roussel A, Vigouroux A, Reilly B, Lepault J, Kielian M, Rey FA. 2004. Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus. Nature. 427: 320-5. PubMed
Comments on 1rer » E1 envelope glycoprotein
E1 is a class II viral fusion protein. This trimeric (low-pH-iduced) form is fusion active, and promotes release of viral nucleocapsid in cytoplasm after cell and viral membrane fusion. Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane. N-terminal domain of this protein: 1dyl(NMR), 1vcp, 1vcq.