PDB ID or protein name

1rsy » Synaptotagmin-1

1rsy » Synaptotagmin-1
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1rsy » Synaptotagmin-1
Depth 2.5 ± 1.6 Å
Tilt Angle 24 ± 17°
ΔGtransfer -4.1 kcal/mol
Links to 1rsy PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.90 Å
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1rsy » Synaptotagmin-1
Side-chains of residues in positions M173, G174, and F234 penetrate into the hydrophobic core of the membrane in the calculated orientation. Experimental membrane depth parameters are positive in positions 174 and 234 (only) but negative in position 173 (Table 2 in Frazier et al. 2003). However, residue M173 was identified as most important for membrane binding by Gerber et al. (2002).
Comments on 1rsy » Synaptotagmin-1
N-terminal residues originating from expression vector have been removed during calculations.