PDB ID or protein name

1s6x » Voltage sensor toxin VSTx1

1s6x » Voltage sensor toxin VSTx1
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Topology in Secreted
Topologyout side
in side
1s6x » Voltage sensor toxin VSTx1
Depth 4.4 ± 1.4 Å
Tilt Angle 79 ± 13°
ΔGtransfer -6.3 kcal/mol
Links to 1s6x PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure 2n1n
Number of subunits 1
Experimental Verification for 1s6x » Voltage sensor toxin VSTx1
Results are consistent with fluorescence and other data of Jung et al. (2005, 2006). Maximal membrane binding affinity is -6.8 kcal/mol (Jung et al. 2005).
2 references
Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Lee DG, Earm YE, Kim JI. 2006. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel.Biochem Biophys Res Commun. 340:633-8. PubMed
Jung HJ, Lee JY, Kim SH, Eu YJ, Shin SY, Milescu M, Swartz KJ, Kim JI. 2005. Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel. Biochemistry. 44: 6015-6023. PubMed
Comments on 1s6x » Voltage sensor toxin VSTx1
Membrane-binding site participates in protein-protein interaction.