PDB ID or protein name

1s7p » Microcin J25, peptide 38-58, cleaved after 47

1s7p » Microcin J25, peptide 38-58, cleaved after 47
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1s7p » Microcin J25, peptide 38-58, cleaved after 47
Hydrophobic Thickness or Depth 4.7 ± 1.2 Å
Tilt Angle 83 ± 18°
ΔGtransfer -5.7 kcal/mol
Links to 1s7p PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries of this protein 1pp5, 1q71
Number of subunits 1
Experimental Verification for 1s7p » Microcin J25, peptide 38-58, cleaved after 47
This is a thermolysin-digested version of the peptide. Due to poor solubility in water, the structure was determined in methanol. See also comments for 1q71.
Comments on 1s7p » Microcin J25, peptide 38-58, cleaved after 47
The peptide works as an antibiotic through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP). Also acts on the cytoplasmic membrane of Salmonella newport, producing alteration of membrane permeability and disruption of the subsequent gradient dissipation, which inhibits several processes essential for cell viability, such as oxygen consumption.