- Protein Classification
- Protein Links
| 1s8i » Myotoxin | |
|---|---|
| Depth | 4.9 ± 0.7 Å |
| Tilt Angle | 83 ± 5° |
| ΔGtransfer | -10.6 kcal/mol |
| Links to 1s8i | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | out |
| Resolution | 1.6 Å |
| Other PDB entries of this protein | 1s8g, 1s8h |
| Number of subunits | 1 |
| 1 reference |
|---|
| Ambrosio AL, Nonato MC, de Araujo HS, Arni R, Ward RJ, Ownby CL, de Souza DH, Garratt RC. 2005. A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change. J Biol Chem. 280: 7326-35. PubMed |
| Comments on 1s8i » Myotoxin |
|---|
| Group II subfamily. Myotoxic protein that presumably lacks PA2 enzymatic activity. Induces necrosis of muscle cells. Three crystal forms of the myotoxin (1s8i, 1s8g and 1s8h) reveal that the presence of a ligand in the active site (naturally presumed to be a fatty acid) induces the exposure of a hydrophobic surface (the hydrophobic knuckle) toward the C terminus (Ambrosio et al. 2004). |
