PDB ID or protein name

1s8i » Myotoxin

1s8i » Myotoxin
Magnify 1s8i » MyotoxinEnlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Secreted
Topologyout side
in side
1s8i » Myotoxin
Depth 4.9 ± 0.7 Å
Tilt Angle 83 ± 5°
ΔGtransfer -10.6 kcal/mol
Links to 1s8i PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.6 Å
Other PDB entries representing this structure 1s8g, 1s8h
Number of subunits 1
1 reference
Ambrosio AL, Nonato MC, de Araujo HS, Arni R, Ward RJ, Ownby CL, de Souza DH, Garratt RC. 2005. A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change. J Biol Chem. 280: 7326-35. PubMed
Comments on 1s8i » Myotoxin
Group II subfamily. Myotoxic protein that presumably lacks PA2 enzymatic activity. Induces necrosis of muscle cells. Three crystal forms of the myotoxin (1s8i, 1s8g and 1s8h) reveal that the presence of a ligand in the active site (naturally presumed to be a fatty acid) induces the exposure of a hydrophobic surface (the hydrophobic knuckle) toward the C terminus (Ambrosio et al. 2004).