- Protein Classification
- Protein Links
 | lumenal side |
| cytoplasmic side |
| 1suo » Cytochrome P450 2B4, closed state 1 | |
|---|---|
| Hydrophobic Thickness | 4.6 ± 1.3 Å |
| Tilt Angle | 57 ± 4° |
| ΔGtransfer | -14.2 kcal/mol |
| Links to 1suo | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | cytoplasmic |
| Resolution | 1.9 Å |
| Other PDB entries of this protein | 3kw4, 3me6, 3mvr, 3tk3, 3tmz, 3uas, 4h1n |
| Number of TM subunits | 1 |
| Experimental Verification for 1suo » Cytochrome P450 2B4, closed state 1 |
|---|
| Membrane-bound. Endoplasmic reticulum. Crystallization with detergent (CYMAL-5). This cytochrome presumably forms TMH 1-21, consistent with calculated orientation. |
| Comments on 1suo » Cytochrome P450 2B4, closed state 1 |
|---|
| Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. |
