PDB ID or protein name

1suo » Cytochrome P450 2B4, closed state 1

1suo » Cytochrome P450 2B4, closed state 1
Magnify 1suo » Cytochrome P450 2B4, closed state 1Enlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1suo » Cytochrome P450 2B4, closed state 1
Hydrophobic Thickness 4.6 ± 1.3 Å
Tilt Angle 57 ± 4°
ΔGtransfer -14.2 kcal/mol
Links to 1suo PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.9 Å
Other PDB entries representing this structure 3kw4, 3me6, 3mvr, 3tk3, 3tmz, 3uas, 4h1n, 4jlt, 4mgj, 5em4, 5iuz
Number of TM subunits 1
Experimental Verification for 1suo » Cytochrome P450 2B4, closed state 1
Membrane-bound. Endoplasmic reticulum. Crystallization with detergent (CYMAL-5). This cytochrome presumably forms TMH 1-21, consistent with calculated orientation.
Comments on 1suo » Cytochrome P450 2B4, closed state 1
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.