PDB ID or protein name

1t6m » Phosphatidylinositol-specific phospholipase C

1t6m » Phosphatidylinositol-specific phospholipase C
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1t6m » Phosphatidylinositol-specific phospholipase C
Depth 3.8 ± 1.4 Å
Tilt Angle 89 ± 13°
ΔGtransfer -4.9 kcal/mol
Links to 1t6m PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 2.1 Å
Other PDB entries of this protein 2or2, 3ea1, 3ea2, 3ea3
Number of subunits 1
Comments on 1t6m » Phosphatidylinositol-specific phospholipase C
Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors. 1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. W47A/W242A mutant (2or2 PDB entry) forms dimer and has different conformation of membrane-interacting loops.