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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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1t7d » Type 1 signal peptidase, complex with lipopeptide inhibitor

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.63. Peptidase SF (1 family)
• Family: 1.1.63.01. Peptidase S26 (4 proteins)
• Species: Escherichia coli (178 proteins)
• Localization: Bacterial Gram-negative inner membrane (269 proteins)

1t7d » Type 1 signal peptidase, complex with lipopeptide inhibitor
Hydrophobic Thickness	3.9 ± 1.0 Å
Tilt Angle	65 ± 11°
ΔGtransfer	-7.6 kcal/mol
Links to 1t7d	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	2.4 Å
Other PDB entries of this protein	none
Number of TM subunits	1

Experimental Verification for 1t7d » Type 1 signal peptidase, complex with lipopeptide inhibitor
This is a two-pass TM protein (UniProt). See comments for 1kn9.

1 reference
Paetzel M, Goodall JJ, Kania M, Dalbey RE, Page MG. 2004. Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor. J Biol Chem. 279:30781-90. PubMed

Comments on 1t7d » Type 1 signal peptidase, complex with lipopeptide inhibitor
Consistent with membrane binding mode proposed by Paetzel et al. (2004).

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA