PDB ID or protein name

1tbn » C1 domain of protein kinase C gamma

1tbn » C1 domain of protein kinase C gamma
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1tbn » C1 domain of protein kinase C gamma
Depth 4.8 ± 1.6 Å
Tilt Angle 42 ± 19°
ΔGtransfer -3.7 kcal/mol
Links to 1tbn PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution NMR
Other PDB entries representing this structure 1tbo
Number of subunits 1
Experimental Verification for 1tbn » C1 domain of protein kinase C gamma
Calculated orientation is in agreement with broadening of amide signals in the presence of lipid micelles (residues 106-111, 113-116, 120-127, and 130) (Xu et al. 1997). However, many of the affected residues are situated in the membrane interface (residues buried in the model: 111, 112, 114, and 118-125). The structure was determined in the presence of 25% CD3CH/75% H2O, due to solubility problems (Xu et al. 1997).
1 reference
Xu RX, Pawelczyk T, Xia TH, Brown SC. 1997. NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. Biochemistry. 36: 10709-10717. PubMed