1tbn » Protein kinase C-gamma
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Topology in Eukaryotic plasma membrane
Download Coordinates
Topology in Eukaryotic plasma membrane
 | extracellular side |
| cytoplasmic side |
- Type: 2. Monotopic/peripheral (4 classes)
- Class: 2.2. All beta monotopic/peripheral (42 superfamilies)
- Superfamily: 2.2.27. C1 domain (1 family)
- Family: 2.2.27.01. Protein kinase C1 domain (8 proteins)
- Species: Rattus rattus (2 proteins)
- Localization: Eukaryotic plasma membrane (198 proteins)
| 1tbn » Protein kinase C-gamma | |
|---|---|
| Depth | 7.5 ± 1.0 Å |
| Tilt Angle | 46 ± 7° |
| ΔGtransfer | -2.3 kcal/mol |
| Links to 1tbn | PDB Sum, SCOP, MSD, OCA, MMDB, Dali |
| Topology | cytoplasmic |
| Resolution | NMR |
| Related PDB Sum entries | 1tbo |
| Number of subunits | 1 |
| Experimental Verification for 1tbn » Protein kinase C-gamma |
|---|
| Calculated orientation is in agreement with broadening of amide signals in the presence of lipid micelles (residues 106-111, 113-116, 120-127, and 130) (Xu et al. 1997). However, many of the affected residues are situated in the membrane interface (residues buried in the model: 111, 112, 114, and 118-125). The structure was determined in the presence of 25% CD3CH/75% H2O, due to solubility problems (Xu et al. 1997). |
| 1 reference |
|---|
| Xu RX, Pawelczyk T, Xia TH, Brown SC. 1997. NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. Biochemistry. 36: 10709-10717. PubMed |
