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• Protein Classification

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1tgx » Cytotoxin 1 ( Cardiotoxin gamma)

• Type: 2. Monotopic/peripheral (4 classes)
• Class: 2.2. All beta monotopic/peripheral (57 superfamilies)
• Superfamily: 2.2.39. Snake toxin-like (2 families) 1.C.74 (TCDB)
• Family: 2.2.39.01. Snake venom toxins (15 proteins) C.1.74 (TCDB)
• Species: Naja mossambica pallida (1 protein)
• Localization: Secreted (681 proteins)

1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
Depth	6.7 ± 1.0 Å
Tilt Angle	59 ± 12°
ΔGtransfer	-10.0 kcal/mol
Links to 1tgx	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	1.5 Å
Other PDB entries of this protein	1cxn, 1cxo
Number of subunits	1

Experimental Verification for 1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
Maximal membrane-binding affinity is -9.6 kcal/mol (Batenburg et al. 1985). Fluorescence quenching shows penetration of the protein into the hydrocarbon interior of the lipid bilayer. The study was probably done for D57N mutant, the toxin from Naja mossambica mossambica (NMR model 2cxx).

1 reference
Batenburg, A.M., Bougis, P.E., Rochat, H., Verkleij, A.J., and de Kruijff, B. 1985. Penetration of a cardiotoxin into cardiolipin model membranes and its implications on lipid organization. Biochemistry. 24:7101-7110. PubMed

Comments on 1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
Shows cytolytic activity (By similarity).

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA