PDB ID or protein name

1tgx » Cytotoxin 1 ( Cardiotoxin gamma)

1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
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1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
Depth 6.7 ± 1.0 Å
Tilt Angle 59 ± 12°
ΔGtransfer -10.0 kcal/mol
Links to 1tgx PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 1.5 Å
Other PDB entries representing this structure 1cxn, 1cxo
Number of subunits 1
Experimental Verification for 1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
Maximal membrane-binding affinity is -9.6 kcal/mol (Batenburg et al. 1985). Fluorescence quenching shows penetration of the protein into the hydrocarbon interior of the lipid bilayer. The study was probably done for D57N mutant, the toxin from Naja mossambica mossambica (NMR model 2cxx).
1 reference
Batenburg, A.M., Bougis, P.E., Rochat, H., Verkleij, A.J., and de Kruijff, B. 1985. Penetration of a cardiotoxin into cardiolipin model membranes and its implications on lipid organization. Biochemistry. 24:7101-7110. PubMed
Comments on 1tgx » Cytotoxin 1 ( Cardiotoxin gamma)
Shows cytolytic activity (By similarity).