PDB ID or protein name

1tz4 » Neuropeptide Y-pancreatic polypeptide hybrid

1tz4 » Neuropeptide Y-pancreatic polypeptide hybrid
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1tz4 » Neuropeptide Y-pancreatic polypeptide hybrid
Hydrophobic Thickness or Depth 5.1 ± 1.0 Å
Tilt Angle 88 ± 8°
ΔGtransfer -6.1 kcal/mol
Links to 1tz4 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
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Resolution NMR
Other PDB entries representing this structure 1tz5
Number of subunits 1
Experimental Verification for 1tz4 » Neuropeptide Y-pancreatic polypeptide hybrid
Structure in DPC micelles (1tz5 is another sequence version in DPC). Penetration of amphiphilic helix 17-32 in the membrane interior was supported by spin-labeling study (Thomas et al. 2005). Membrane binding affinity at pH=7.4 was -4.7 kcal/mol (Thomas et al. 2005).
2 references
Bader R and Zerbe O (2005) Are hormones from the neuropeptide Y family recognized by their receptors from the membrane-bound state? Chembiochem. 6: 1520-1534. PubMed
Thomas, L., Scheidt, H.A., Bettio, A., Huster, D., Beck-Sickinger, A.G., Arnold, K., and Zschornig, O. 2005. Membrane interaction of neuropeptide Y detected by EPR and NMR spectroscopy. Biochim. Biophys. Acta. 1714:103-113. PubMed