PDB ID or protein name

1w3w » Annexin VIII

1w3w » Annexin VIII
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1w3w » Annexin VIII
Depth 4.1 ± 1.0 Å
Tilt Angle 79 ± 9°
ΔGtransfer -6.2 kcal/mol
Links to 1w3w PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.9 Å
Other PDB entries representing this structure 1w45
Number of subunits 1
1 reference
Rety S, Sopkova-de Oliveira Santos J, Dreyfuss L, Blondeau K, Hofbauerova K, Raguenes-Nicol C, Kerboeuf D, Renouard M, Russo-Marie F, Lewit-Bentley A. 2005. The crystal structure of annexin A8 is similar to that of annexin A3. J Mol Biol. 345:1131-9. PubMed
Comments on 1w3w » Annexin VIII
This annexin is normally expressed in endothelial cells of the placenta and the lung. It may have a role in the signal transduction pathway in the acute promyelocytic leukemia cells. The structure of the K16A mutant of annexin A8 reveals the conformation of an intact medium-length annexin N terminus, including two highly accessible functional regulation sites, a calpain cleavage site and a potential phosphorylation site. The regulation would take place by releasing the N terminus from restrictive interactions within the hydrophilic channel between the annexin structural modules, releasing their full flexibility (Rety et al. 2005).