PDB ID or protein name

1w6k » Lanosterol synthase

1w6k » Lanosterol synthase
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1w6k » Lanosterol synthase
Depth 7.6 ± 1.0 Å
Tilt Angle 77 ± 4°
ΔGtransfer -17.8 kcal/mol
Links to 1w6k PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.1 Å
Other PDB entries representing this structure 1w6j
Number of subunits 1
Experimental Verification for 1w6k » Lanosterol synthase
Consistent with orientation proposed by Thoma et al. (2004). This is an integral monotopic protein.
1 reference
Thoma R, Schulz-Gasch T, DArcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A. 2004. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Nature 432:118-22. PubMed
Comments on 1w6k » Lanosterol synthase
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, first step of cholesterol biosynthesis.