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• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

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1w6k » Lanosterol synthase

• Type: 2. Monotopic/peripheral (4 classes)
• Class: 2.1. All alpha monotopic/peripheral (60 superfamilies)
• Superfamily: 2.1.05. Six-hairpin glycosidase superfamily (2 families)
• Family: 2.1.05.01. Terpene synthases (2 proteins)
• Species: Homo sapiens (443 proteins)
• Localization: Endoplasmic reticulum membrane (125 proteins)

1w6k » Lanosterol synthase
Depth	7.6 ± 1.0 Å
Tilt Angle	77 ± 4°
ΔGtransfer	-17.8 kcal/mol
Links to 1w6k	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	cytoplasmic
Resolution	2.1 Å
Other PDB entries of this protein	1w6j
Number of subunits	1

Experimental Verification for 1w6k » Lanosterol synthase
Consistent with orientation proposed by Thoma et al. (2004). This is an integral monotopic protein.

1 reference
Thoma R, Schulz-Gasch T, DArcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A. 2004. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Nature 432:118-22. PubMed

Comments on 1w6k » Lanosterol synthase
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, first step of cholesterol biosynthesis.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA