PDB ID or protein name

1wpg » Calcium ATPase, E2-Pi state, conformation 1

1wpg » Calcium ATPase, E2-Pi state, conformation 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1wpg » Calcium ATPase, E2-Pi state, conformation 1
Hydrophobic Thickness 30.6 ± 1.1 Å
Tilt Angle 20 ± 0°
ΔGtransfer -70.4 kcal/mol
Links to 1wpg PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus cytoplasmic)
Resolution 2.30 Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 10
1 transmembrane subunit
A - Tilt: 21° - Segments: 1(60-77), 2(89-104), 3(256-274), 4(292-306), 5(760-780), 6(789-807), 7(834-854), 8(896-915), 9(932-949), 10(966-987)
Experimental Verification for 1wpg » Calcium ATPase, E2-Pi state, conformation 1
Results are consistent with data about biological activity of ATPase in bilayers of various hydrophobic thicknesses (Cornea and Thomas 1994, Lee 1998).
2 references
Cornea RL, and Thomas DD (1994) Effect of membrane thickness on the molecular dynamics and enzymatic activity of reconstituted Ca-ATPase. Biochemistry 33: 2912-2920. PubMed
Lee AG (1998) How lipids interact with an intrinsic membrane protein: the case of the calcium pump. Biochim. Biophys. Acta 1376: 381-390. PubMed
Comments on 1wpg » Calcium ATPase, E2-Pi state, conformation 1
Similar conformational states are indicated as related PDB entries