PDB ID or protein name

1xq8 » Alpha-synuclein

1xq8 » Alpha-synuclein
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1xq8 » Alpha-synuclein
Depth 8.7 ± 1.1 Å
Tilt Angle 87 ± 4°
ΔGtransfer -15.7 kcal/mol
Links to 1xq8 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution NMR
Other PDB entries representing this structure 2kkw
Number of subunits 1
Experimental Verification for 1xq8 » Alpha-synuclein
This is structure in micelles. The helices must rearrange to fit the plane. According to spin-labeling data, residues T59, V63, G67, V70, V74, V77, T81, A85 and A89 are buried in the hydrophobic interior of the membrane, while residues E61, N65, G68, T72, A76, Q79, and E83 are exposed to water in the membrane-bound state (Jao et al. 2004).
1 reference
Jao, C.C., Der-Sarkissian, A., Chen, J., and Langen, R. 2004. Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proc. Natl. Acad. Sci. U. S. A. 101:8331-8336. PubMed
Comments on 1xq8 » Alpha-synuclein
The protein is involved in the regulation of dopamine release and transport. Normally, this is a soluble protein, localized primarily at the presynaptic region of axons. However it can also form filamentous aggregates that are that are involved in several neurodegenerative diseases. This structure is probably a misfolded state, which is formed in the presence of detergents or in lipid bilayers.