PDB ID or protein name

1xt7 » Daptomycin, Ca-free

1xt7 » Daptomycin, Ca-free
Magnify 1xt7 » Daptomycin, Ca-freeEnlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Secreted
Topologyout side
in side
1xt7 » Daptomycin, Ca-free
Hydrophobic Thickness or Depth 9.3 ± 3.9 Å
Tilt Angle 10 ± 45°
ΔGtransfer -6.4 kcal/mol
Links to 1xt7 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1xt7 » Daptomycin, Ca-free
Kyn14 residue is situated at the lipid-water interface and penetrates deeper into the membrane in the Ca-bound state (Lakey and Ptak 1988).
Comments on 1xt7 » Daptomycin, Ca-free
Daptomycin is a cyclic anionic lipopeptide antibiotic recently approved for the treatment of complicated skin infections (Cubicin). Its function is dependent on calcium (as Ca2+). The NMR structure of daptomycin indicated that Ca2+ induced a conformational change in daptomycin that increased its amphipathicity (Jung et al. 2004).