- Protein Classification
- Protein Links
| 1xt7 » Daptomycin, Ca-free | |
|---|---|
| Hydrophobic Thickness or Depth | 9.3 ± 3.9 Å |
| Tilt Angle | 10 ± 45° |
| ΔGtransfer | -6.4 kcal/mol |
| Links to 1xt7 | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | out |
| Resolution | NMR |
| Other PDB entries representing this structure | 1t5m, 1t5n |
| Number of subunits | 1 |
| Experimental Verification for 1xt7 » Daptomycin, Ca-free |
|---|
| Kyn14 residue is situated at the lipid-water interface and penetrates deeper into the membrane in the Ca-bound state (Lakey and Ptak 1988). |
| Comments on 1xt7 » Daptomycin, Ca-free |
|---|
| Daptomycin is a cyclic anionic lipopeptide antibiotic recently approved for the treatment of complicated skin infections (Cubicin). Its function is dependent on calcium (as Ca2+). The NMR structure of daptomycin indicated that Ca2+ induced a conformational change in daptomycin that increased its amphipathicity (Jung et al. 2004). |
