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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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• Species (538 species)
• Localization (24 types)
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1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1

• Type: 1. Transmembrane (3 classes)
• Class: 1.2. Alpha-helical bitopic (42 superfamilies)
• Superfamily: 1.2.33. Transmembrane proteins with NAD(P)-binding Rossmann-fold domains (2 families)
• Family: 2.3.04.01. Tyrosine-dependent oxidoreductases (6 proteins)
• Species: Homo sapiens (443 proteins)
• Localization: Endoplasmic reticulum membrane (125 proteins)

1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
Hydrophobic Thickness	7.9 ± 0.2 Å
Tilt Angle	89 ± 1°
ΔGtransfer	-20.2 kcal/mol
Links to 1xu7	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	lumenal
Resolution	1.8 Å
Other PDB entries of this protein	1xu9, 2bel, 2ilt, 2irw, 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3fco, 3frj, 3h6k, 3hfg, 3oq1, 3qqp, 3tfq, 4bb5, 4bb6, 4hfr
Number of TM subunits	2

Experimental Verification for 1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
N-terminal segment 7-23 from each subunit was shown to form a TM helix (single-pass type II membrane protein), consistent with calculated orientation of the dimer.

Comments on 1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
Membrane binding mode is slightly asymmetric, because conformations of segments 228-233 in the monomeric units are different.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA