PDB ID or protein name

1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1

1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
Hydrophobic Thickness 7.9 ± 0.2 Å
Tilt Angle 89 ± 1°
ΔGtransfer -20.2 kcal/mol
Links to 1xu7 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology lumenal
Resolution 1.8 Å
Other PDB entries representing this structure 1xu9, 2bel, 2ilt, 2irw, 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3fco, 3frj, 3h6k, 3hfg, 3oq1, 3qqp, 3tfq, 4bb5, 4bb6, 4c7j, 4c7k, 4hfr, 4hx5, 4iju, 4ijv, 4ijw, 4k1l, 4p38, 4yyz, 5pgu, 5pgv, 5pgw, 5pgx, 5pgy
Number of TM subunits 2
Experimental Verification for 1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
N-terminal segment 7-23 from each subunit was shown to form a TM helix (single-pass type II membrane protein), consistent with calculated orientation of the dimer.
Comments on 1xu7 » Corticosteroid 11-beta-dehydrogenase, isozyme 1
Membrane binding mode is slightly asymmetric, because conformations of segments 228-233 in the monomeric units are different.