1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1
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Topology in Endoplasmic reticulum membrane
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Topology in Endoplasmic reticulum membrane
 | lumenal side |
| cytoplasmic side |
- Type: 2. Monotopic/peripheral (4 classes)
- Class: 2.3. Alpha/Beta monotopic/peripheral (20 superfamilies)
- Superfamily: 2.3.04. NAD(P)-binding Rossmann-fold domains (1 family)
- Family: 2.3.04.01. Tyrosine-dependent oxidoreductases (3 proteins)
- Species: Mus musculus (33 proteins)
- Localization: Endoplasmic reticulum membrane (48 proteins)
| 1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1 | |
|---|---|
| Depth | 3.6 ± 0.3 Å |
| Tilt Angle | 89 ± 3° |
| ΔGtransfer | -14.9 kcal/mol |
| Links to 1y5m | PDB Sum, SCOP, MSD, OCA, MMDB, Dali |
| Topology | lumenal |
| Resolution | 2.3 Å |
| Related PDB Sum entries | 1y5r |
| Number of subunits | 2 |
| Experimental Verification for 1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1 |
|---|
| N-terminal segment 7-23 from each subunit was shown to form a TM helix (single-pass type II membrane protein). The dimer of water-soluble domains presumably associates with membranes through the C-terminal helices (Zhang et al. 2005), as calculated. |
| 1 reference |
|---|
| Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR. 2005 Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes. Biochemistry. 44:6948-57. PubMed |
