![]() | lumenal side |
| cytoplasmic side |
| 1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1 | |
|---|---|
| Depth | 3.6 ± 0.3 Å |
| Tilt Angle | 89 ± 3° |
| ΔGtransfer | -14.9 kcal/mol |
| Links to 1y5m | PDB Sum, SCOP, MSD, OCA, MMDB, Dali |
| Topology | lumenal |
| Resolution | 2.3 Å |
| Related PDB Sum entries | 1y5r |
| Number of subunits | 2 |
| Experimental Verification for 1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1 |
|---|
| N-terminal segment 7-23 from each subunit was shown to form a TM helix (single-pass type II membrane protein). The dimer of water-soluble domains presumably associates with membranes through the C-terminal helices (Zhang et al. 2005), as calculated. |
| 1 reference |
|---|
| Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR. 2005 Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes. Biochemistry. 44:6948-57. PubMed |