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1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1

• Type: 1. Transmembrane (3 classes)
• Class: 1.2. Alpha-helical bitopic (42 superfamilies)
• Superfamily: 1.2.33. Transmembrane proteins with NAD(P)-binding Rossmann-fold domains (2 families)
• Family: 2.3.04.01. Tyrosine-dependent oxidoreductases (6 proteins)
• Species: Mus musculus (78 proteins)
• Localization: Endoplasmic reticulum membrane (125 proteins)

1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1
Hydrophobic Thickness	4.6 ± 0.4 Å
Tilt Angle	89 ± 2°
ΔGtransfer	-19.3 kcal/mol
Links to 1y5m	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	lumenal
Resolution	2.3 Å
Other PDB entries of this protein	1y5r, 3gmd
Number of TM subunits	2

Experimental Verification for 1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1
N-terminal segment 7-23 from each subunit was shown to form a TM helix (single-pass type II membrane protein). The dimer of water-soluble domains presumably associates with membranes through the C-terminal helices (Zhang et al. 2005), as calculated.

1 reference
Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR. 2005 Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes. Biochemistry. 44:6948-57. PubMed

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA