PDB ID or protein name

1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1

1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1
Hydrophobic Thickness 4.6 ± 0.4 Å
Tilt Angle 89 ± 2°
ΔGtransfer -19.3 kcal/mol
Links to 1y5m PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology lumenal
Resolution 2.3 Å
Other PDB entries representing this structure 1y5r, 3gmd, 4k1l, 4k26, 4nmh
Number of TM subunits 2
Experimental Verification for 1y5m » Corticosteroid 11-beta-dehydrogenase, isozyme 1
N-terminal segment 7-23 from each subunit was shown to form a TM helix (single-pass type II membrane protein). The dimer of water-soluble domains presumably associates with membranes through the C-terminal helices (Zhang et al. 2005), as calculated.
1 reference
Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR. 2005 Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes. Biochemistry. 44:6948-57. PubMed