PDB ID or protein name

1z10 » Cytochrome P450 2A6

1z10 » Cytochrome P450 2A6
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
1z10 » Cytochrome P450 2A6
Hydrophobic Thickness 5.0 ± 1.7 Å
Tilt Angle 44 ± 18°
ΔGtransfer -9.5 kcal/mol
Links to 1z10 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.9 Å
Other PDB entries representing this structure 1z11, 2fdu, 2fdv, 2fdw, 2fdy, 2pg5, 2pg6, 2pg7, 3ebs, 3t3q, 3t3r, 4ejj, 4rui
Number of TM subunits 1
Experimental Verification for 1z10 » Cytochrome P450 2A6
Crystallization with detergent (ANAPOE-X-405). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation.
Comments on 1z10 » Cytochrome P450 2A6
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. 2p85 is a nearly identical structure of P450 2a13.