PDB ID or protein name

1z64 » Pleurocidin

1z64 » Pleurocidin
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Topology in Secreted
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in side
1z64 » Pleurocidin
Hydrophobic Thickness or Depth 5.4 ± 1.3 Å
Tilt Angle 87 ± 18°
ΔGtransfer -12.8 kcal/mol
Links to 1z64 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution NMR
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 1z64 » Pleurocidin
Calculated position is in agreement with burial of W2 in the membrane core (flurescence data) and with the overall orientation and membrane penetration depth of the peptide determined by solid-state NMR (Mason et al. 2006). 3D structure was determined in DPC micelles. Each micelle contains at least two pleurocidin molecules. The peptide forms ion channels in lipid bilayers.
1 reference
Mason AJ, Chotimah IN, Bertani P, Bechinger B. 2006. A spectroscopic study of the membrane interaction of the antimicrobial peptide Pleurocidin. Mol Membr Biol. 23: 185-194. PubMed
Comments on 1z64 » Pleurocidin
Antimicrobial peptide with potent activity against Gram-positive and Gram-negative bacteria. Inhibits nucleic acid and protein synthesis.