PDB ID or protein name

1zza » Stannin

1zza » Stannin
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Topology in Mitochondrial outer membrane
Topologyintermembrane space side
cytoplasmic side
1zza » Stannin
Hydrophobic Thickness 30.0 ± 2.0 Å
Tilt Angle 13 ± 2°
ΔGtransfer -25.2 kcal/mol
Links to 1zza PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus intermembrane space)
Resolution NMR
Other PDB entries representing this structure none
Number of TM Secondary Structures 1
1 transmembrane subunit
A - Tilt: 13° - Segments: 1(10-28)
2 references
Buck-Koehntop BA, Mascioni A, Buffy JJ, Veglia G. 2005. Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. J Mol Biol. 354:652-665. PubMed
Davidson CE, Reese BE, Billingsley ML, Yun JK. 2004. Stannin, a protein that localizes to the mitochondria and sensitizes NIH-3T3 cells to trimethyltin and dimethyltin toxicity. Mol Pharmacol. 66: 855-863. PubMed
Comments on 1zza » Stannin
This is structure in SDS micelles. Calculated orientation and hydrophobic thickness of this protein are unreliable, because the experimental structure was determined by combining distance constraints obtained for individual alpha-helices in micelles with orientational constraints obtained in the lipid bilayer (Buck-Koehntop et al. 2005). The transmembrane topology is tentative (Davidson et al. 2004).