PDB ID or protein name

2agc » Ganglioside GM2 activator

2agc » Ganglioside GM2 activator
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Topology in Lysosome membrane
Topologyout side
in side
2agc » Ganglioside GM2 activator
Depth 3.2 ± 1.0 Å
Tilt Angle 54 ± 12°
ΔGtransfer -5.3 kcal/mol
Links to 2agc PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology out
Resolution 2.5 Å
Other PDB entries representing this structure none
Number of subunits 1
Experimental Verification for 2agc » Ganglioside GM2 activator
GM2 activator interacts with lipid bilayers (Giehl et al. 1999). Calculated orientation is in agreement with membrane binding mode proposed by Wright et al. (2003).
2 references
Giehl A, Lemm T, Bartelsen O, Sandhoff K, Blume A. 1999. Interaction of the GM2-activator protein with phospholipid-ganglioside bilayer membranes and with monolayers at the air-water interface. Eur J Biochem. 261:650-8. PubMed
Wright CS, Zhao Q, Rastinejad F. 2003. Structural analysis of lipid complexes of GM2-activator protein. J Mol Biol. 331:951-64. PubMed
Comments on 2agc » Ganglioside GM2 activator
Extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.