PDB ID or protein name

2agv » Calcium ATPase, E2 state (Ca-free), conformation 1

2agv » Calcium ATPase, E2 state (Ca-free), conformation 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
2agv » Calcium ATPase, E2 state (Ca-free), conformation 1
Hydrophobic Thickness 29.7 ± 2.2 Å
Tilt Angle 20 ± 2°
ΔGtransfer -61.5 kcal/mol
Links to 2agv PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus cytoplasmic)
Resolution 2.4 Å
Other PDB entries representing this structure 1iwo, 2dqs, 3ar3, 3ar4, 3ar5, 3ar6, 3ar7, 3w5c, 3w5d
Number of TM Secondary Structures 10
1 transmembrane subunit
A - Tilt: 21° - Segments: 1(60-77), 2(89-103), 3(259-274), 4(288-306), 5(762-780), 6(789-807), 7(832-853), 8(896-915), 9(932-949), 10(967-986)
Experimental Verification for 2agv » Calcium ATPase, E2 state (Ca-free), conformation 1
Results are consistent with data about biological activity of ATPase in bilayers of various hydrophobic thicknesses (Cornea and Thomas 1994, Lee 1998).
2 references
Cornea RL, and Thomas DD (1994) Effect of membrane thickness on the molecular dynamics and enzymatic activity of reconstituted Ca-ATPase. Biochemistry 33: 2912-2920. PubMed
Lee AG (1998) How lipids interact with an intrinsic membrane protein: the case of the calcium pump. Biochim. Biophys. Acta 1376: 381-390. PubMed
Comments on 2agv » Calcium ATPase, E2 state (Ca-free), conformation 1
Similar conformational states are indicated as related PDB entries