PDB ID or protein name

2bdm » Cytochrome P450 2B4, open state 1

2bdm » Cytochrome P450 2B4, open state 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
2bdm » Cytochrome P450 2B4, open state 1
Hydrophobic Thickness 10.6 ± 1.0 Å
Tilt Angle 48 ± 15°
ΔGtransfer -16.2 kcal/mol
Links to 2bdm PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.3 Å
Other PDB entries representing this structure none
Number of TM subunits 1
Comments on 2bdm » Cytochrome P450 2B4, open state 1
This cytochrome forms a nonnative interwinded dimer in crystal. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.