2bg9 » Acetylcholine receptor
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Topology in Eukaryotic plasma membrane
Download Coordinates
Topology in Eukaryotic plasma membrane
 | extracellular side |
| cytoplasmic side |
- Type: 1. Transmembrane (2 classes)
- Class: 1.1. Alpha-helical transmembrane (55 superfamilies)
- Superfamily: 1.1.26. Pentameric ligand-gated ion channels (2 families) 1.A.9 (TCDB)
- Family: 1.1.26.01. Ligand-gated ion channel of neurotransmitter receptors (1 protein) 1.A.9 (TCDB)
- Species: Torpedo marmorata (1 protein)
- Localization: Eukaryotic plasma membrane (198 proteins)
| 2bg9 » Acetylcholine receptor | |
|---|---|
| Hydrophobic Thickness | 31.0 ± 1.6 Å |
| Tilt Angle | 3 ± 2° |
| ΔGtransfer | -158.0 kcal/mol |
| Links to 2bg9 | PDB Sum, SCOP, MSD, OCA, MMDB, Dali |
| Topology | subunit A (N-terminus extracellular) |
| Resolution | 4.00 Å |
| Related PDB Sum entries | 1oed |
| Number of TM Secondary Structures | 20 |
| 5 transmembrane subunits |
|---|
| A - Tilt: 16° - Segments: 1(212-234), 2(244-265), 3(276-297), 4(409-433) |
| B - Tilt: 13° - Segments: 1(220-241), 2(250-271), 3(282-303), 4(438-463) |
| C - Tilt: 9° - Segments: 1(229-249), 2(258-279), 3(290-313), 4(456-479) |
| D - Tilt: 9° - Segments: 1(214-235), 2(244-265), 3(278-300), 4(409-430) |
| E - Tilt: 15° - Segments: 1(221-242), 2(252-273), 3(285-308), 4(449-473) |
| Experimental Verification for 2bg9 » Acetylcholine receptor |
|---|
| The shallow location of Trp452 from the G subunit of the nicotinic acetylcholine receptor (1.4 A° below the calculated hydrophobic boundary) is consistent with fluorescence studies (Chattopadhyay and McNamee 1991). |
| 1 reference |
|---|
| Chattopadhyay A, and McNamee MG (1991) Average membrane penetration depth of tryptophan residues of the nicotinic acetylcholine receptor by the parallax method. Biochemistry 30: 7159-7164. PubMed |
