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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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• Species (538 species)
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2bg9 » Nicotinic acetylcholine receptor, closed state

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.15. Pentameric ligand-gated ion channels (2 families) 1.A.9 (TCDB)
• Family: 1.1.15.01. Ligand-gated ion channel of neurotransmitter receptors (7 proteins) 1.A.9 (TCDB)
• Species: Torpedo marmorata (2 proteins)
• Localization: Eukaryotic plasma membrane (479 proteins)

2bg9 » Nicotinic acetylcholine receptor, closed state
Hydrophobic Thickness	30.1 ± 1.1 Å
Tilt Angle	3 ± 0°
ΔGtransfer	-119.6 kcal/mol
Links to 2bg9	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus extracellular)
Resolution	4.00 Å
Other PDB entries of this protein	1oed
Number of TM Secondary Structures	20

5 transmembrane subunits
A - Tilt: 15° - Segments: 1(213-233), 2(244-265), 3(276-297), 4(409-433)
B - Tilt: 14° - Segments: 1(220-240), 2(251-271), 3(282-303), 4(438-463)
C - Tilt: 10° - Segments: 1(229-249), 2(258-279), 3(289-313), 4(457-479)
D - Tilt: 8° - Segments: 1(215-235), 2(244-264), 3(278-299), 4(409-430)
E - Tilt: 14° - Segments: 1(221-242), 2(252-273), 3(285-306), 4(449-470)

Experimental Verification for 2bg9 » Nicotinic acetylcholine receptor, closed state
The shallow location of Trp452 from the G subunit of the nicotinic acetylcholine receptor (1.4 A° below the calculated hydrophobic boundary) is consistent with fluorescence studies (Chattopadhyay and McNamee 1991).

1 reference
Chattopadhyay A, and McNamee MG (1991) Average membrane penetration depth of tryptophan residues of the nicotinic acetylcholine receptor by the parallax method. Biochemistry 30: 7159-7164. PubMed

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA