PDB ID or protein name

2bg9 » Nicotinic acetylcholine receptor, closed state

2bg9 » Nicotinic acetylcholine receptor, closed state
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
2bg9 » Nicotinic acetylcholine receptor, closed state
Hydrophobic Thickness 30.1 ± 1.1 Å
Tilt Angle 3 ± 0°
ΔGtransfer -119.6 kcal/mol
Links to 2bg9 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus extracellular)
Resolution 4.00 Å
Other PDB entries representing this structure 1oed, 4bog, 4boi, 4bon, 4boo, 4bor, 4bot
Number of TM Secondary Structures 20
5 transmembrane subunits
A - Tilt: 15° - Segments: 1(213-233), 2(244-265), 3(276-297), 4(409-433)
B - Tilt: 14° - Segments: 1(220-240), 2(251-271), 3(282-303), 4(438-463)
C - Tilt: 10° - Segments: 1(229-249), 2(258-279), 3(289-313), 4(457-479)
D - Tilt: 8° - Segments: 1(215-235), 2(244-264), 3(278-299), 4(409-430)
E - Tilt: 14° - Segments: 1(221-242), 2(252-273), 3(285-306), 4(449-470)
Experimental Verification for 2bg9 » Nicotinic acetylcholine receptor, closed state
The shallow location of Trp452 from the G subunit of the nicotinic acetylcholine receptor (1.4 A° below the calculated hydrophobic boundary) is consistent with fluorescence studies (Chattopadhyay and McNamee 1991).
1 reference
Chattopadhyay A, and McNamee MG (1991) Average membrane penetration depth of tryptophan residues of the nicotinic acetylcholine receptor by the parallax method. Biochemistry 30: 7159-7164. PubMed