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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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2crd » Charybdotoxin

• Type: 2. Monotopic/peripheral (4 classes)
• Class: 2.4. Alpha + Beta monotopic/peripheral (50 superfamilies)
• Superfamily: 2.4.16. Scorpion toxin-like knottin (11 families)
• Family: 2.4.16.03. Short-chain scorpion toxins (5 proteins)
• Species: Leiurus quinquestriatus hebraeus (4 proteins)
• Localization: Secreted (681 proteins)

2crd » Charybdotoxin
Depth	1.1 ± 1.5 Å
Tilt Angle	86 ± 15°
ΔGtransfer	-3.2 kcal/mol
Links to 2crd	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	out
Resolution	NMR
Other PDB entries of this protein	1bah
Number of subunits	1

Experimental Verification for 2crd » Charybdotoxin
Experimental membrane bindig affinity is -2.0 kcal/mol (0.2 M KCl) to -3.6 kcal/mol (0.1 M KCl), and up to -8 kcal/mol at lower non-physiological ionic strength (Ben-Tal et al. 1997).

1 reference
Ben-Tal, N., Honig, B., Miller, C., and McLaughlin, S. 1997. Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles. Biophys. J. 73:1717-1727. PubMed

Comments on 2crd » Charybdotoxin
Membrane-binding site participates in association with potassium channel (see structure of the complex, 2a9h).

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA