- Protein Classification
- Protein Links
 | lumenal side |
| cytoplasmic side |
| 2f9q » Cytochrome P450 2D6, conformation 1 | |
|---|---|
| Hydrophobic Thickness | 7.0 ± 1.8 Å |
| Tilt Angle | 29 ± 10° |
| ΔGtransfer | -12.0 kcal/mol |
| Links to 2f9q | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | cytoplasmic |
| Resolution | 3.0 Å |
| Other PDB entries of this protein | none |
| Number of TM subunits | 1 |
| Comments on 2f9q » Cytochrome P450 2D6, conformation 1 |
|---|
| Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Highly polymorphic. Induction by pregnancy. D230 and R231 were replaced by Leu (to be as in wild type protein). |
