PDB ID or protein name

2f9q » Cytochrome P450 2D6, conformation 1

2f9q » Cytochrome P450 2D6, conformation 1
Magnify 2f9q » Cytochrome P450 2D6, conformation 1Enlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
2f9q » Cytochrome P450 2D6, conformation 1
Hydrophobic Thickness 7.0 ± 1.8 Å
Tilt Angle 29 ± 10°
ΔGtransfer -12.0 kcal/mol
Links to 2f9q PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 3.0 Å
Other PDB entries representing this structure none
Number of TM subunits 1
Comments on 2f9q » Cytochrome P450 2D6, conformation 1
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. Highly polymorphic. Induction by pregnancy. D230 and R231 were replaced by Leu (to be as in wild type protein).