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• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

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2hyd » Multidrug ABC transporter SAV1866, closed state

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.10. ABC transporters (5 families) 3.A.1 (TCDB)
• Family: 1.1.10.03. Lipid/drug exporters (4 proteins) 3.A.1.106 (TCDB)
• Species: Staphylococcus aureus (19 proteins)
• Localization: Bacterial Gram-positive plasma membrane (81 proteins)

2hyd » Multidrug ABC transporter SAV1866, closed state
Hydrophobic Thickness	31.8 ± 1.7 Å
Tilt Angle	3 ± 3°
ΔGtransfer	-110.5 kcal/mol
Links to 2hyd	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus in)
Resolution	3.0 Å
Other PDB entries of this protein	2onj, 4a82
Number of TM Secondary Structures	12

2 transmembrane subunits
A - Tilt: 6° - Segments: 1(16-37), 2(60-82), 3(136-158), 4(161-182), 5(243-265), 6(283-304)
B - Tilt: 2° - Segments: 1(13-37), 2(62-85), 3(136-159), 4(161-181), 5(245-266), 6(283-303)

Comments on 2hyd » Multidrug ABC transporter SAV1866, closed state
TM portions of this transporter and lipid flippases have completely different 3D stuctures, although the proteins are homologous. EM-based model of homologous transporter from E.coli (2i68) also seems to be different.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA