PDB ID or protein name

2i36 » Rhodopsin, inactive state, a dimer

2i36 » Rhodopsin, inactive state, a dimer
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
2i36 » Rhodopsin, inactive state, a dimer
Hydrophobic Thickness 30.0 ± 1.4 Å
Tilt Angle 4 ± 4°
ΔGtransfer -125.6 kcal/mol
Links to 2i36 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus extracellular)
Resolution 4.1 Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 14
2 transmembrane subunits
A - Tilt: 15° - Segments: 1(38-63), 2(73-95), 3(112-133), 4(151-171), 5(202-224), 6(254-275), 7(286-308)
B - Tilt: 24° - Segments: 1(35-63), 2(71-95), 3(112-134), 4(149-171), 5(203-224), 6(254-277), 7(286-307)
Comments on 2i36 » Rhodopsin, inactive state, a dimer
Two structures of retinal-free opsin (2i36 and 2i37) contain a loosely packed dimer formed through association of TM helices I. This is one of several GPCR dimerization modes discussed in the literature. Similar I-to-I dimers were found in 2D crystals of rhodopsin (Krebs et al. 2003). However, tilts of invividual molecules of rhodopsin with respect to non-crystallographic C2 symmetry axis in 2D crystals were smaller.