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• Protein Classification

• Types (3 types)
• Classes (11 classes)
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• Species (539 species)
• Localization (24 types)
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2i36 » Rhodopsin, inactive state, a dimer

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.01. Rhodopsin-like receptors and pumps (4 families) 3.E.1 (TCDB)
• Family: 1.1.01.02. G-protein coupled receptors, family A (47 proteins) 9.A.14 (TCDB)
• Species: Bos taurus (64 proteins)
• Localization: Eukaryotic plasma membrane (483 proteins)

2i36 » Rhodopsin, inactive state, a dimer
Hydrophobic Thickness	30.0 ± 1.4 Å
Tilt Angle	4 ± 4°
ΔGtransfer	-125.6 kcal/mol
Links to 2i36	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus extracellular)
Resolution	4.1 Å
Other PDB entries representing this structure	none
Number of TM Secondary Structures	14

2 transmembrane subunits
A - Tilt: 15° - Segments: 1(38-63), 2(73-95), 3(112-133), 4(151-171), 5(202-224), 6(254-275), 7(286-308)
B - Tilt: 24° - Segments: 1(35-63), 2(71-95), 3(112-134), 4(149-171), 5(203-224), 6(254-277), 7(286-307)

Comments on 2i36 » Rhodopsin, inactive state, a dimer

Two structures of retinal-free opsin (2i36 and 2i37) contain a loosely packed dimer formed through association of TM helices I. This is one of several GPCR dimerization modes discussed in the literature. Similar I-to-I dimers were found in 2D crystals of rhodopsin (Krebs et al. 2003). However, tilts of invividual molecules of rhodopsin with respect to non-crystallographic C2 symmetry axis in 2D crystals were smaller.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA