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• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (393 superfamilies)
• Families (668 families)
• Species (539 species)
• Localization (24 types)
• All proteins in OPM (2185 proteins)

• Protein Links

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2iqr » Melanocortin-4 receptor model (active state) with agonist NDP-MSH

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.01. Rhodopsin-like receptors and pumps (4 families) 3.E.1 (TCDB)
• Family: 1.1.01.02. G-protein coupled receptors, family A (47 proteins) 9.A.14 (TCDB)
• Species: Homo sapiens (443 proteins)
• Localization: Eukaryotic plasma membrane (483 proteins)

2iqr » Melanocortin-4 receptor model (active state) with agonist NDP-MSH
Hydrophobic Thickness	33.5 ± 2.0 Å
Tilt Angle	24 ± 0°
ΔGtransfer	-60.6 kcal/mol
Links to 2iqr	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus extracellular)
Resolution	model Å
Other PDB entries representing this structure	none
Number of TM Secondary Structures	7

1 transmembrane subunit
A - Tilt: 23° - Segments: 1(48-67), 2(81-105), 3(121-149), 4(164-187), 5(192-217), 6(244-270), 7(282-304)

1 reference
Pogozheva ID, Chai BX, Lomize AL, Fong TM, Weinberg DH, Nargund RP, Mulholland MW, Gantz I, Mosberg HI. 2005. Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists. Biochemistry. 44: 11329-11341. PubMed

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA