• HOME
• ABOUT OPM
• DOWNLOAD OPM FILES
• CONTACT US
• PPM SERVER
• LIPID COMPOSITION ATLAS

• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

• Protein Links

• PDB Sum,
• PDB,
• OCA,
• MPKS,
• PDBTM,
• MPDB,
• CGDB

2iqv » Melanocortin-4 receptor model (inactive state) with antagonist AGRP

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.01. Rhodopsin-like receptors and pumps (4 families) 3.E.1 (TCDB)
• Family: 1.1.01.02. G-protein coupled receptors, family A (47 proteins) 9.A.14 (TCDB)
• Species: Homo sapiens (443 proteins)
• Localization: Eukaryotic plasma membrane (479 proteins)

2iqv » Melanocortin-4 receptor model (inactive state) with antagonist AGRP
Hydrophobic Thickness	31.9 ± 1.1 Å
Tilt Angle	19 ± 0°
ΔGtransfer	-49.1 kcal/mol
Links to 2iqv	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus extracellular)
Resolution	model Å
Other PDB entries of this protein	none
Number of TM Secondary Structures	7

1 transmembrane subunit
A - Tilt: 19° - Segments: 1(48-67), 2(81-105), 3(121-149), 4(164-187), 5(192-217), 6(246-267), 7(282-305)

1 reference
Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I. 2005. Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry. 44: 3418-31. PubMed

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA