PDB ID or protein name

2iqv » Melanocortin-4 receptor model (inactive state) with antagonist AGRP

2iqv » Melanocortin-4 receptor model (inactive state) with antagonist AGRP
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
2iqv » Melanocortin-4 receptor model (inactive state) with antagonist AGRP
Hydrophobic Thickness 31.9 ± 1.1 Å
Tilt Angle 19 ± 0°
ΔGtransfer -49.1 kcal/mol
Links to 2iqv PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus extracellular)
Resolution model Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 7
1 transmembrane subunit
A - Tilt: 19° - Segments: 1(48-67), 2(81-105), 3(121-149), 4(164-187), 5(192-217), 6(246-267), 7(282-305)
1 reference
Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I. 2005. Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry. 44: 3418-31. PubMed