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2jo1 » Na,K-ATPase regulatory protein FXYD1 (phospholemman)

• Type: 1. Transmembrane (3 classes)
• Class: 1.2. Alpha-helical bitopic (42 superfamilies)
• Superfamily: 1.2.25. Single-helix ATPase regulators (2 families)
• Family: 1.2.25.02. FXYD regulators (2 proteins) 1.A.27 (TCDB)
• Species: Homo sapiens (443 proteins)
• Localization: Endoplasmic reticulum membrane (125 proteins)

2jo1 » Na,K-ATPase regulatory protein FXYD1 (phospholemman)
Hydrophobic Thickness	30.6 ± 2.5 Å
Tilt Angle	11 ± 4°
ΔGtransfer	-27.8 kcal/mol
Links to 2jo1	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus lumenal)
Resolution	NMR
Other PDB entries of this protein	none
Number of TM Secondary Structures	1

1 transmembrane subunit
A - Tilt: 11° - Segments: 1(15-37)

Experimental Verification for 2jo1 » Na,K-ATPase regulatory protein FXYD1 (phospholemman)
A slightly larger tilt angle (15 compare to 8+-3 degree) was obtained in solid-state NMR study (Franzin et al. 2007).

1 reference
Franzin CM, Gong XM, Thai K, Yu J, Marassi FM. 2007. NMR of membrane proteins in micelles and bilayers: the FXYD family proteins. Methods. 41: 398-408. PubMed

Comments on 2jo1 » Na,K-ATPase regulatory protein FXYD1 (phospholemman)
This is structure in SDS micelles.

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA