- Protein Classification
- Protein Links
 | out side |
| in side |
| 2oau » Mechanosensitive channel protein MscS, expanded state | |
|---|---|
| Hydrophobic Thickness | 31.8 ± 0.8 Å |
| Tilt Angle | 1 ± 1° |
| ΔGtransfer | -171.3 kcal/mol |
| Links to 2oau | PDB Sum, PDB, SCOP, MSD, OCA, MMDB |
| Topology | subunit A (N-terminus out) |
| Resolution | 3.70 Å |
| Other PDB entries of this protein | none |
| Number of TM Secondary Structures | 14 |
| 7 transmembrane subunits |
|---|
| A - Tilt: 34° - Segments: 1(28-48), 2(77-89), 3(93-97) |
| B - Tilt: 33° - Segments: 1(28-48), 2(77-89), 3(93-97) |
| C - Tilt: 29° - Segments: 1(28-47), 2(77-89), 3(93-97) |
| D - Tilt: 30° - Segments: 1(28-48), 2(77-89), 3(93-97) |
| E - Tilt: 31° - Segments: 1(28-48), 2(77-89), 3(93-97) |
| F - Tilt: 35° - Segments: 1(28-48), 2(77-89), 3(93-97) |
| G - Tilt: 27° - Segments: 1(28-44), 2(78-89), 3(93-97) |
| 2 references |
|---|
| Akitake B, Anishkin A, Sukharev S. 2005. The "dashpot" mechanism of stretch-dependent gating in MscS. J Gen Physiol. 125:143-5. PubMed |
| Bass, R.B., Strop, P., Barclay, M., and Rees, D.C. 2002. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science 298: 1582–1587. PubMed |
| Comments on 2oau » Mechanosensitive channel protein MscS, expanded state |
|---|
| This is an open or another expanded state of the mechanosensor (Bass et al. 2002, Akitake et al. 2005). MscS is inserted in the "monotopic" mode (it does not transverse the bilayer), due to the missing (disordered) N-terminal segment of alpha-helix in each of seven subunits. Key voltage-sensitive arginines remain outside of the calculated hydrophobic slab, in the lipid head group region. |
