PDB ID or protein name

2oau » Mechanosensitive channel protein MscS, expanded state

2oau » Mechanosensitive channel protein MscS, expanded state
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Topology in Bacterial Gram-negative inner membrane
Topologyout side
in side
2oau » Mechanosensitive channel protein MscS, expanded state
Hydrophobic Thickness 31.8 ± 0.8 Å
Tilt Angle 1 ± 1°
ΔGtransfer -171.3 kcal/mol
Links to 2oau PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus out)
Resolution 3.70 Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 14
7 transmembrane subunits
A - Tilt: 34° - Segments: 1(28-48), 2(77-89), 3(93-97)
B - Tilt: 33° - Segments: 1(28-48), 2(77-89), 3(93-97)
C - Tilt: 29° - Segments: 1(28-47), 2(77-89), 3(93-97)
D - Tilt: 30° - Segments: 1(28-48), 2(77-89), 3(93-97)
E - Tilt: 31° - Segments: 1(28-48), 2(77-89), 3(93-97)
F - Tilt: 35° - Segments: 1(28-48), 2(77-89), 3(93-97)
G - Tilt: 27° - Segments: 1(28-44), 2(78-89), 3(93-97)
2 references
Akitake B, Anishkin A, Sukharev S. 2005. The "dashpot" mechanism of stretch-dependent gating in MscS. J Gen Physiol. 125:143-5. PubMed
Bass, R.B., Strop, P., Barclay, M., and Rees, D.C. 2002. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science 298: 1582–1587. PubMed
Comments on 2oau » Mechanosensitive channel protein MscS, expanded state
This is an open or another expanded state of the mechanosensor (Bass et al. 2002, Akitake et al. 2005). MscS is inserted in the "monotopic" mode (it does not transverse the bilayer), due to the missing (disordered) N-terminal segment of alpha-helix in each of seven subunits. Key voltage-sensitive arginines remain outside of the calculated hydrophobic slab, in the lipid head group region.