PDB ID or protein name

2q7r » FLAP protein (5-lipoxygenase activator)

2q7r » FLAP protein (5-lipoxygenase activator)
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
2q7r » FLAP protein (5-lipoxygenase activator)
Hydrophobic Thickness 30.3 ± 1.3 Å
Tilt Angle 0 ± 1°
ΔGtransfer -70.8 kcal/mol
Links to 2q7r PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus lumenal)
Resolution 4.00 Å
Other PDB entries representing this structure 2q7m
Number of TM Secondary Structures 12
3 transmembrane subunits
A - Tilt: 16° - Segments: 1(3-24), 2(63-77), 3(80-94), 4(116-138)
B - Tilt: 16° - Segments: 1(3-24), 2(63-77), 3(80-94), 4(116-138)
C - Tilt: 16° - Segments: 1(3-24), 2(63-77), 3(80-94), 4(116-138)
Comments on 2q7r » FLAP protein (5-lipoxygenase activator)
Hydrophobic thickness is poorly defined due to significant misplacement of C-terminal helix, probably induced by binding of inhibitor, like C4 leucotriene synthase (2uuh). This protein interacts with lipoxygenase (see 1lox in OPM).