PDB ID or protein name

2spc » Spectrin alpha chain

2spc » Spectrin alpha chain
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
2spc » Spectrin alpha chain
Depth 4.3 ± 0.8 Å
Tilt Angle 87 ± 11°
ΔGtransfer -6.2 kcal/mol
Links to 2spc PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 1.8 Å
Other PDB entries representing this structure none
Number of subunits 2
Experimental Verification for 2spc » Spectrin alpha chain
Subcellular location: near the inner surface of the plasma membrane of nearly all cells. Interacts with lipid bilayers (Maksymiw et al. 1987).
1 reference
Maksymiw, R., Sui, S.F., Gaub, H., and Sackmann, E. 1987. Electrostatic coupling of spectrin dimers to phosphatidylserine containing lipid lamellae. Biochemistry. 26:2983-2990. PubMed
Comments on 2spc » Spectrin alpha chain
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Native spectrin molecule is a tetramer composed of two antiparallel heterodimers joined head to head so that each end of the native molecule includes the C-terminus of the alpha subunit and the N-terminus of the beta subunit.