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2zbd » Calcium ATPase, E1P-ADP state

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.09. P-type ATPase (P-ATPase) (1 family) 3.A.3 (TCDB)
• Family: 1.1.09.01. P-ATPase (35 proteins) 3.A.3 (TCDB)
• Species: Oryctolagus cuniculus (37 proteins)
• Localization: Endoplasmic reticulum membrane (125 proteins)

2zbd » Calcium ATPase, E1P-ADP state
Hydrophobic Thickness	31.8 ± 1.4 Å
Tilt Angle	22 ± 2°
ΔGtransfer	-70.6 kcal/mol
Links to 2zbd	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus cytoplasmic)
Resolution	2.40 Å
Other PDB entries of this protein	none
Number of TM Secondary Structures	10

1 transmembrane subunit
A - Tilt: 22° - Segments: 1(60-78), 2(84-104), 3(259-281), 4(288-310), 5(759-781), 6(789-807), 7(832-854), 8(895-916), 9(933-950), 10(964-987)

Experimental Verification for 2zbd » Calcium ATPase, E1P-ADP state
Results are consistent with data about biological activity of ATPase in bilayers of various hydrophobic thicknesses (Cornea and Thomas 1994, Lee 1998).

2 references
Cornea RL, and Thomas DD (1994) Effect of membrane thickness on the molecular dynamics and enzymatic activity of reconstituted Ca-ATPase. Biochemistry 33: 2912-2920. PubMed
Lee AG (1998) How lipids interact with an intrinsic membrane protein: the case of the calcium pump. Biochim. Biophys. Acta 1376: 381-390. PubMed

Comments on 2zbd » Calcium ATPase, E1P-ADP state
Similar conformational states are indicated as related PDB entries

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA