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• Protein Classification

• Types (3 types)
• Classes (11 classes)
• Superfamilies (392 superfamilies)
• Families (667 families)
• Species (538 species)
• Localization (24 types)
• All proteins in OPM (2172 proteins)

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2zz9 » Aquaporin-4, different conformation of loops with lipids

• Type: 1. Transmembrane (3 classes)
• Class: 1.1. Alpha-helical polytopic (72 superfamilies)
• Superfamily: 1.1.14. Major Intrinsic Protein (MIP)/FNT superfamily (2 families) 1.A.8 (TCDB)
• Family: 1.1.14.01. Major intrinsic protein (MIP) family (20 proteins) 1.A.8 (TCDB)
• Species: Rattus norvegicus (74 proteins)
• Localization: Eukaryotic plasma membrane (479 proteins)

2zz9 » Aquaporin-4, different conformation of loops with lipids
Hydrophobic Thickness	29.5 ± 0.7 Å
Tilt Angle	0 ± 0°
ΔGtransfer	-115.6 kcal/mol
Links to 2zz9	PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology	subunit A (N-terminus cytoplasmic)
Resolution	2.80 Å
Other PDB entries of this protein	none
Number of TM Secondary Structures	28

4 transmembrane subunits
A - Tilt: 5° - Segments: 1(34-56), 2(70-90), 3(98-107), 4(112-133), 5(156-177), 6(189-204), 7(231-252)
G - Tilt: 5° - Segments: 1(34-56), 2(70-90), 3(98-107), 4(112-136), 5(156-177), 6(189-204), 7(231-252)
M - Tilt: 5° - Segments: 1(34-56), 2(70-90), 3(98-107), 4(112-133), 5(156-177), 6(189-204), 7(231-252)
S - Tilt: 5° - Segments: 1(34-56), 2(70-90), 3(98-107), 4(112-133), 5(156-177), 6(189-204), 7(231-252)

Copyright © 2005-2013 Andrei Lomize, Mikhail Lomize and Irina Pogozheva
University of Michigan, Ann Arbor, MI 48109 USA