PDB ID or protein name

3bkd » M2 proton channel of Influenza A, open state, ligand-free

3bkd » M2 proton channel of Influenza A, open state, ligand-free
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Topology in Viral membrane
Topologyout side
in side
3bkd » M2 proton channel of Influenza A, open state, ligand-free
Hydrophobic Thickness 27.1 ± 1.8 Å
Tilt Angle 3 ± 1°
ΔGtransfer -55.0 kcal/mol
Links to 3bkd PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit E (N-terminus out)
Resolution 2.05 Å
Other PDB entries representing this structure 1mp6, 1nyj, 2h95, 2kad, 2rlf, 3c9j
Number of TM Secondary Structures 4
4 transmembrane subunits
E - Tilt: 37° - Segments: 1(25-44)
F - Tilt: 37° - Segments: 1(25-44)
G - Tilt: 34° - Segments: 1(25-44)
H - Tilt: 32° - Segments: 1(25-44)
Comments on 3bkd » M2 proton channel of Influenza A, open state, ligand-free
This detergent-disordered structure is not exactly symmetric. Subunits (helices) G and H are closer packed with each other than others. Two crystal structures (3bkd and 3c9j) are close to each other (CA atom rmsd of 1.1 A) but strongly differ from NMR structure, 2rlf (rmsd of 3.8-3.9 A). 3c9j is similar to amantadine-bound solid state NMR model 2h95 (rmsd of 2.4A).