PDB ID or protein name

3c9j » M2 proton channel of Influenza A, open state, complex with amantadine

3c9j » M2 proton channel of Influenza A, open state, complex with amantadine
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Topology in Viral membrane
Topologyout side
in side
3c9j » M2 proton channel of Influenza A, open state, complex with amantadine
Hydrophobic Thickness 29.4 ± 1.4 Å
Tilt Angle 2 ± 3°
ΔGtransfer -65.6 kcal/mol
Links to 3c9j PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus out)
Resolution 3.50 Å
Other PDB entries of this protein 1nyj, 2h95, 2kad, 2rlf, 3bkd
Number of TM Secondary Structures 4
4 transmembrane subunits
A - Tilt: 36° - Segments: 1(4-24)
B - Tilt: 34° - Segments: 1(4-24)
C - Tilt: 37° - Segments: 1(4-24)
D - Tilt: 36° - Segments: 1(4-24)
Comments on 3c9j » M2 proton channel of Influenza A, open state, complex with amantadine
The tetramer is not exactly symmetric. Two crystal structures (3bkd and 3c9j) are close to each other (CA atom rmsd of 1.1 A) but strongly differ from NMR structure, 2rlf (rmsd of 3.8-3.9 A). This structure is similar to amantadine-bound solid state NMR model 2h95 (rmsd of 2.4A).