PDB ID or protein name

4uis » Gamma-secretase complex, structure 2

4uis » Gamma-secretase complex, structure 2
Magnify 4uis » Gamma-secretase complex, structure 2Enlarged view of image
3D view in Jmol or Webmol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
4uis » Gamma-secretase complex, structure 2
Hydrophobic Thickness 36.8 ± 0.1 Å
Tilt Angle 11 ± 2°
ΔGtransfer -59.6 kcal/mol
Links to 4uis PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus lumenal)
Resolution 4.4 Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 20
4 transmembrane subunits
A - Tilt: 11° - Segments: 1( 666- 686)
B - Tilt: 18° - Segments: 1( 81- 101), 2( 151- 155), 3( 168- 189), 4( 195- 215), 5( 221- 241), 6( 247- 269), 7( 382- 399), 8( 404- 424), 9( 434- 453)
C - Tilt: 12° - Segments: 1( 7- 22), 2( 45- 57), 3( 74- 99), 4( 113- 137), 5( 151- 155), 6( 181- 202), 7( 203- 220)
D - Tilt: 9° - Segments: 1( 11- 19), 2( 22- 30), 3( 49- 57)
Comments on 4uis » Gamma-secretase complex, structure 2
The calculated hydrophobic thickness is very approximate because a number of TM segments have undefined amino acid sequence (UNK residues).