PDB ID or protein name

5a63 » Gamma-secretase complex, structure 1

5a63 » Gamma-secretase complex, structure 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
5a63 » Gamma-secretase complex, structure 1
Hydrophobic Thickness 29.8 ± 0.6 Å
Tilt Angle 5 ± 0°
ΔGtransfer -129.6 kcal/mol
Links to 5a63 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology subunit A (N-terminus lumenal)
Resolution 3.4 Å
Other PDB entries representing this structure none
Number of TM Secondary Structures 17
4 transmembrane subunits
A - Tilt: 12° - Segments: 1( 669- 690)
B - Tilt: 15° - Segments: 1( 85- 102), 2( 171- 186), 3( 195- 214), 4( 221- 240), 5( 243- 260), 6( 383- 399), 7( 403- 421), 8( 436- 458)
C - Tilt: 5° - Segments: 1( 4- 26), 2( 32- 56), 3( 70- 91), 4( 118- 139), 5( 157- 179), 6( 187- 207), 7( 211- 231)
D - Tilt: 5° - Segments: 1( 58- 79)
Comments on 5a63 » Gamma-secretase complex, structure 1
Second TMH in subunit B is missing/disordered in the crystal structure. Two membrane-penetrating helices from subunit D are interpreted as a re-entrance loop.